CK-17 Monoclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-22039-60, E-AB-22039-120, E-AB-22039-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CK17

Target Synonym: 39.1; CK 17; CK-17; Cytokeratin-17; K17; K1C17; Keratin 17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4; Keratin 17; type I; Keratin; Keratin type I cytoskeletal 17; keratin; type i cytoskeletal 17 [version 1]; Keratin-17; KRT17; PC; PC2; PCHC1; type I cytoskeletal 17

Research Areas: Cancer, Signal Transduction

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human

Application: WB, IHC-p, IF, IP

Isotype: IgG

Clonality: Monoclonal

Clone No.: Clone:2K5

UNIProt ID: Q04695

Background: May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification Method: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300

Calculated MW: 48kDa

Observed MW: 48kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only